Conclusions

• A reduced neuron model excitatory network can produce synchronized bursting activity.

• Local activity of group of neurons can cause sequential activation of adjacent aggregates of neurons and synchronous activity that propagates from one region to another.

• A small number of local excitatory connections (two per neuron ) in the absence of inhibition can produce the spread of epileptiform activity with velocities comparable to those observed in neocortex.

• Velocities of spread increase with the increase of synaptic strength and range of connections but is relatively independent of the pattern of connections.

Supported by NIH 33732-01 and KBN 8T11B-02013.