Understanding the mechanisms of generation and propagation of synchronous epileptiform activity in neural networks is important for investigating the dynamics of seizure spread in epileptic patients. Experimental models of synchronous neural activity including hippocampal slice[1], neocortical slice[2] and cultures of dissociated spinal cord neurons[3] allow measurements of basic physiologic parameters of neurons capable of generation and spread of synchronous activity. The hippocampal slice has been used extensively as the basis for neural network models[1] of highly organized neural circuits. These simulations reveal generation and rapid spread of epileptiform activity in hippocampal circuits. Cultures of dissociated spinal cord neurons have spread of synchronous activity in less organized networks of neurons. This may serve as model of spread of synchronous activity in networks of neurons without specific circuitry. Although neocortical seizures in humans may appear to spread rapidly, measurements of the velocities of propagation of epileptiform activity in neocortical tissue[2] indicate that propagation is significantly slower than the axon propagation speed and slower than in hippocampal slices. This suggests the possibility that this process is a cooperative phenomenon involving a large number of sparsely connected cells.