Conclusions

• The presented model allows for detailed investigations of the nature of difficult to localize clinically relevant events associated with seizure origination from areas with rapid regional spread.

• Spatiotemporal patterns observed in networks vary depending on the type of focus but the frequencies of bursts observed in remote neurons are dependant by membrane characteristics and are not primarily dependent on the characteristics of focus.

• Local inhomogeneity (lesion) in networks resulting from synaptic reorganization may act similar to an external focus e.g. to promote origination of recurrent neuronal bursting and facilitate regional spread in the surrounding area.