Analysis of dynamics of seizure spread in time and space
Modeling of seizure dynamics and propagation
Detection of nonstationary signals
Gregory K. Bergey, M.D.  - Professor, Director Epilepsy Center, neurologist, physiologist
Christophe Jouny, Ph.D. - Assistant Professor, Co-Director Epilepsy Research Laboratory, biomedical engineer
Joanne Barnett - Senior Medical Office Coordinator
Former lab members
Piotr J. Franaszczuk, Ph.D. - Associate Professor on professional leave to ARL, physicist
Piotr Suffczynski, Ph.D. -Visiting Assistant Professor, physicist
Pawel Kudela, Ph.D. - Assistant Professor, physicist
Keun-Hang Susan Yang, Ph.D. - neurscientist, Post-doctoral fellow 2001-2003, present: Chapman University, Orange,CA
W. Stanley Anderson, Ph.D.,M.D. - physisist, neurosurgery resident
2002-2008, present:Assistant Professor of Neurosurgery, Johns Hopkins School of Medicine
Calcium Involvement in Regulation of Neuronal Bursting in Disinhibited Neuronal Networks: Insights from Calcium Studies in a Spherical Cell Model. Biophys. J.; 97:3065-74 (2009),
Partial seizures are associated with early increases in signal complexity.Clin.Neurophysiol.121:7-13(2010)
Phase-dependent stimulation effects on bursting activity in a neural network cortical simulation.Epilepsy Res. 84:42-55 (2009)
Studies of stimulus parameters for seizure disruption using neural network simulation Biological Cybernetics 97:173-194 (2007)
Intrinsic Ictal Dynamics at the Seizure Focus: Effects of Secondary Generalization Revealed by Complexity MeasuresEpilepsia 48:297-304 (2007)
Computationally efficient approaches to calculating significant ERD/ERS changes in the time-frequency plane J. Neurosc. Meth.145:267-276 (2005)
Signal Complexity and Synchrony of Epileptic Seizures: Is there an Identifiable Preictal Period? Clin Neurophysiol. 116(3):552-558 (2005)Inhibition modifies the effects of slow calcium-activated potassium channels on epileptiform activity in a neuronal network model. Biological Cybernetics 92:71-81 (2005)
Human ECoG analysis during speech perception using matching pursuit: a comparison between stochastic and dyadic dictionaries. IEEE Trans. Biomed. Eng. 50:1371-1373 (2003)
The influences of somatic and dendritic inhibition on bursting patterns in a neuronal circuit model. Biological Cybernetics 89:242-253 (2003)
Time-frequency analysis using the matching pursuit algorithm applied to seizures originating from the mesial temporal lobe. (abstract) (manuscript pdf) Electroenceph.clin. Neurophysiol. 106:513-521 (1998)
AES'07Kudela, P; Anderson, WS; Franaszczuk, PJ; Bergey, GK. 2007. Studies of calcium current dysfunction in network models of epileptiform activity. EPILEPSIA 48: 118-118, Suppl. 6
Korzeniewska, A; Jouny, CC; Kus, R; Crone, NE; Bergey, GK; Franaszczuk, PJ. 2007. Analysis of activity flows in multiple epileptic seizures. EPILEPSIA 48: 196-196, Suppl. 6.
Jouny, C; Afra, P; Franaszczuk, PJ; Bergey, GK. 2007. Is high-frequency activity relevant to seizure onset localization. EPILEPSIA 48: 199-200, Suppl. 6.
Afra, P; Jouny, CC; Franaszczuk, PJ; Bergey, GK. 2007. Propagation patterns of neocortical seizures may be helpful in predicting surgical outcomes. EPILEPSIA 48: 200-200, Suppl. 6.
Anderson, WS; Kudela, P; Bergey, GK; Franaszczuk, PJ. 2007. Spontaneous seizure onset, termination, and stimulation induced effects in a neural network cortical simulation. EPILEPSIA 48: 302-303, Suppl. 6.
AES'06Jouny, CC; Afra, P; Brown, MA; Franaszczuk, PJ; Bergey, GK. 2006. Complexity analysis of peri-ictal electrodecremental patterns. EPILEPSIA 47: 41-41, Suppl. 4.
Korzeniewska, A; Kus, R; Franaszczuk, PJ; Crainiceanu, C; Crone, NE. 2006. Functional interaction between language and sensorimotor cortex during word production is reflected by event-related causality in electrocorticographic gamma frequencies. EPILEPSIA 47: 42-43, Suppl. 4.
Afra, P; Jouny, CC; Franaszczuk, PJ; Bergey, GK. 2006. Partial seizure duration may influence patterns of seizure termination. EPILEPSIA 47: 48-48, Suppl. 4.
Anderson, WS; Kudela, P; Franaszczuk, PJ; Bergey, GK. 2006. Neural network simulation of cortical stimulation for seizure control. EPILEPSIA 47: 58-58, Suppl. 4.
Kudela, P; Anderson, WS; Franaszczuk, PJ; Bergey, GK. 2006. Mechanism of recurrent neuronal bursting resulting from short-term synaptic depression. EPILEPSIA 47: 221-222, Suppl. 4.
AES'05Koubeissi, MZ; Bergey, GK; Jouny, C; Franaszczuk, P. 2005. Analysis of dynamics of parietal cingulate seizures with secondary mesial temporal involvement. EPILEPSIA 46: 29-29, Suppl. 8.
Sinai, A; Franaszczuk, PJ; Crone, NE. 2005. Electrocorticographic spectral responses during auditory vs. visual lexical semantic processing. EPILEPSIA 46: 71-72, Suppl. 8.
Kudela, P; Franaszczuk, PJ; Bergey, GK. 2005. Activation of synaptic plasticity by electrical stimulation and its effect on supression of epiletiform activity. EPILEPSIA 46: 112-112, Suppl. 8.
Jouny, CC; Franaszczuk, PJ; Bergey, GK. 2005. The time-frequency signature of partial seizure onsets. EPILEPSIA 46: 317-317, Suppl. 8.
Korzeniewska, A; Kus, R; Franaszczuk, P; Crainiceanu, C; Crone, NE. 2005. Dynamic high-gamma interactions during language-related task performance. EPILEPSIA 46: 317-317, Suppl. 8.
IEEE Neural Engineering'05Complexity-based Analysis of the Dynamic of Propagation of Epileptic Seizures. Proceedings of the 2nd International IEEE EMBS Conference on Neural Engineering, Arlington, Virginia, March 16 - 19, 2005: p155-157. (abstract - pdf & poster - pdf)
Synaptic and Cellular Influences on the Composite EEG Signal During Seizures. Proceedings of the 2nd International IEEE EMBS Conference on Neural Engineering, Arlington, Virginia, March 16 - 19, 2005: p245-247 (pdf)
EMBS'04Gabor Atom Density as a Measure of Seizure Complexity. Proceedings of the 26th Annual International Conference of the IEEE EMBS San Francisco, CA, USA September 1-5, 2004: p310-312 vol.1. (pdf)
Software system for data management and distributed processing of multichannel biomedical signals Proceedings of the 26th Annual International Conference of the IEEE EMBS San Francisco, CA, USA September 1-5, 2004: p983-985 vol.2. (pdf)
Synaptic plasticity in neuronal network models can explain patterns of bursting activity seen in temporal lobe epiletic seizures. Proceedings of the 26th Annual International Conference of the IEEE EMBS San Francisco, CA, USA September 1-5, 2004: p715-717 vol.1 (pdf)
AES'04Seizure evolution can be affected by seizure induced changes in synaptic efficacy. Epilepsia 45 (Suppl. 7):199-200 (2004) (poster - pdf)
Propagation of Partial Seizures is Associated with Increased Signal Complexity Near Seizure Focus. Epilepsia 45 (Suppl. 7):61 (2004) ( poster - pdf)
AES'03Reduction of intracellular calcium clearance rate can explain changes in seizure dynamics: studies in neuronal network models. Epilepsia 44 (Suppl.9):193 (2003) (poster - pdf)
Patterns of organized rhythmic activity in neocortical epilepsy. Epilepsia 44 (Suppl.9):230 (2003) (poster - pdf)
CNS'03The influence of slow calcium-activated potassium channels on epileptiform activity in a neuronal model of pyramidal cells. (abstract) (poster - pdf)
AES'02Sequential multichannel Gabor atom density for seizure localization. Epilepsia 43 (Suppl.7):47 (2002) (poster - pdf)
CNS'02The effect of changes in the inhibitory interneuron connectivity on the pattern of bursting behavior in a pyramidal cell model. (text-pdf) (poster - pdf)
AES/ACNS'01Periodic stimuli can induce oscillating activity in simulated neural networks. Epilepsia 42 (Suppl.7):121 (2001) (abstract) (poster)
AES'00Combined multichannel autoregressive and time-frequency analysis of intracranial recordings of complex partial seizures. Epilepsia 41 (Suppl.7):203 (2000) (abstract) (poster)
ACNS'00Analysis of coherence in multiple epileptic seizures. (abstract) (slide show)
World Congress on Medical Physics and Biomedical EngineeringRealistic modeling of large networks of neurons. Medical Physics 27:1391 (abstract) (slide show)
AES'99Seizure termination in neural network models of neocortical neurons. Epilepsia 40 (Suppl.7):12 (1999) (abstract) (poster)
AES'98A neural network model of traveling seizure activity wave. Epilepsia 39 (Suppl.6):3 (1998) (abstract)
Directed transfer function analysis of participation of mesial temporal structures in complex partial seizures with temporal neocortical onset. Epilepsia 39 (Suppl.6):67 (1998) (abstract)
WNM'98A neural network model of propagation of burst activity. (abstract) (poster)
AES'97Application of multichannel autoregressive techniques to measure synchronization of cortical EEG during the preictal, ictal, and postictal periods. Epilepsia 38 (Suppl.8):116 (1997) (abstract) (poster)
AES'96Application of time-frequency transform analysis to hippocampal activity in mesial temporal seizures. Epilepsia 37 (Suppl.5):144 (1996) (abstract) (poster)
SFN'96Time-frequency analysis of mesial temporal lobe seizures using the matching pursuit algorithm. (abstract) (poster)
AES'95Multichannel autoregressive analysis of propagation of mesial temporal lobe seizures. Epilepsia 36 (Suppl.4):69 (1995) (abstract) (poster)
The Cognitive Neurophysiology Laboratory, JHU
Clinical and Computational Auditory Neuroscience, JHU
Department of Biomedical Physics, Warsaw University, Warsaw, Poland
Epilepsy Research Laboratory, Department of Neurology, Johns Hopkins University, Meyer 2-147, 600 N Wolfe St., Baltimore, MD 21287.
For clinical information see: EPILEPSY CENTER