DEPARTMENT OF NEUROLOGY

EPILEPSY CENTER

Personnel

Publications

Conference presentations

Collaborators

Research interests

Tools and methods

Information for Patients

Research interests

Localization of seizure onset in patients with epilepsy 

Analysis of dynamics of seizure spread in time and space 

Modeling of seizure dynamics and propagation 

Detection of nonstationary signals 

Tools and methods

Multichannel autoregressive model, directed transfer function method

Matching pursuit time-frequency analysis

Computer simulation of neural networks 

Animal model of a seizure 

Laboratory Personnel

Gregory K. Bergey, M.D.  - Professor, Director Epilepsy Center, neurologist, physiologist 

Piotr J. Franaszczuk, Ph.D.  - Associate Professor, physicist 

Pawel Kudela, Ph.D. - Assistant Professor, physicist 

Christophe Jouny, Ph.D. - Assistant Professor, biomedical engineer 

W. Stanley Anderson M.D., Ph.D. - Assistant Resident  

Joanne Barnett - Senior Medical Office Coordinator

Former lab members

Keun-Hang Susan Yang, Ph.D. - Post-doctoral fellow, neuroscientist 

Publications

Papers

Studies of stimulus parameters for seizure disruption using neural network simulations Biological Cybernetics 97:173-194

Intrinsic Ictal Dynamics at the Seizure Focus: Effects of Secondary Generalization Revealed by Complexity MeasuresEpilepsia 48:297-304 (2007)

Computationally efficient approaches to calculating significant ERD/ERS changes in the time-frequency plane J. Neurosc. Meth.145:267-276 (2005)

Signal Complexity and Synchrony of Epileptic Seizures: Is there an Identifiable Preictal Period? Clin Neurophysiol. 116(3):552-558 (2005)

Inhibition modifies the effects of slow calcium-activated potassium channels on epileptiform activity in a neuronal network model. Biological Cybernetics 92:71-81 (2005)

Reduction of intracellular calcium removal rate can explain changes in seizure dynamics: studies in neuronal network models. (manuscript pdf) Epilepsy Research 57:95-109 (2003)

Human ECoG analysis during speech perception using matching pursuit: a comparison between stochastic and dyadic dictionaries. IEEE Trans. Biomed. Eng. 50:1371-1373 (2003)

The influences of somatic and dendritic inhibition on bursting patterns in a neuronal circuit model. Biological Cybernetics 89:242-253 (2003)

Changing excitation and inhibition in simulated neural networks: effects on induced bursting behavior. (manuscript pdf) Biological Cybernetics 88:276-285 (2003)

External stimuli can terminate bursting in neural network models. (manuscript pdf) Epilepsy Research 53:65-80 (2003)

Characterization of epileptic seizure dynamics using Gabor atom density. (manuscript pdf) Clin. Neurophysiol. 114:426-437 (2003)

External termination of recurrent bursting in a model of connected local neural sub-networks. (manuscript pdf) Neurocomputing 44-46:897-905 (2002)

Epileptic seizures are characterized by changing signal complexity. (abstract) (manuscript pdf) Clin. Neurophysiol. 112:241-249 (2001)

An autoregressive method for the measurement of synchronization of interictal and ictal EEG signal. (abstract) (manuscript pdf) Biological Cybernetics 81:3-9 (1999)

Model of the propagation of synchronous firing in a reduced neuron network. (abstract) (manuscript pdf) Neurocomputing 26-27:411-418 (1999)

Time-frequency analysis using the matching pursuit algorithm applied to seizures originating from the mesial temporal lobe. (abstract) (manuscript pdf) Electroenceph.clin. Neurophysiol. 106:513-521 (1998)

Application of the directed transfer function method to mesial and lateral onset temporal lobe seizures. (abstract) (manuscript pdf) Brain Topography 11:13-21 (1998) 

A simple computer model of excitable synaptically connected neurons. (abstract) (manuscript pdf) Biological Cybernetics 77:71-77 (1997)

Detection of spontaneous postsynaptic potentials. (abstract) Comp. Biomed. Res. 28:354-370 (1995)

Analysis of mesial temporal seizure onset and propagation using the directed transfer function method. (abstract) (manuscript pdf) Electroenceph. clin. Neurophys. 91:413-427 (1994)
 

Conference presentations

AES'07

Kudela, P; Anderson, WS; Franaszczuk, PJ; Bergey, GK. 2007. Studies of calcium current dysfunction in network models of epileptiform activity. EPILEPSIA 48: 118-118, Suppl. 6

Korzeniewska, A; Jouny, CC; Kus, R; Crone, NE; Bergey, GK; Franaszczuk, PJ. 2007. Analysis of activity flows in multiple epileptic seizures. EPILEPSIA 48: 196-196, Suppl. 6.

Jouny, C; Afra, P; Franaszczuk, PJ; Bergey, GK. 2007. Is high-frequency activity relevant to seizure onset localization. EPILEPSIA 48: 199-200, Suppl. 6.

Afra, P; Jouny, CC; Franaszczuk, PJ; Bergey, GK. 2007. Propagation patterns of neocortical seizures may be helpful in predicting surgical outcomes. EPILEPSIA 48: 200-200, Suppl. 6.

Anderson, WS; Kudela, P; Bergey, GK; Franaszczuk, PJ. 2007. Spontaneous seizure onset, termination, and stimulation induced effects in a neural network cortical simulation. EPILEPSIA 48: 302-303, Suppl. 6.

AES'06

Jouny, CC; Afra, P; Brown, MA; Franaszczuk, PJ; Bergey, GK. 2006. Complexity analysis of peri-ictal electrodecremental patterns. EPILEPSIA 47: 41-41, Suppl. 4.

Korzeniewska, A; Kus, R; Franaszczuk, PJ; Crainiceanu, C; Crone, NE. 2006. Functional interaction between language and sensorimotor cortex during word production is reflected by event-related causality in electrocorticographic gamma frequencies. EPILEPSIA 47: 42-43, Suppl. 4.

Afra, P; Jouny, CC; Franaszczuk, PJ; Bergey, GK. 2006. Partial seizure duration may influence patterns of seizure termination. EPILEPSIA 47: 48-48, Suppl. 4.

Anderson, WS; Kudela, P; Franaszczuk, PJ; Bergey, GK. 2006. Neural network simulation of cortical stimulation for seizure control. EPILEPSIA 47: 58-58, Suppl. 4.

Kudela, P; Anderson, WS; Franaszczuk, PJ; Bergey, GK. 2006. Mechanism of recurrent neuronal bursting resulting from short-term synaptic depression. EPILEPSIA 47: 221-222, Suppl. 4.

AES'05

Koubeissi, MZ; Bergey, GK; Jouny, C; Franaszczuk, P. 2005. Analysis of dynamics of parietal cingulate seizures with secondary mesial temporal involvement. EPILEPSIA 46: 29-29, Suppl. 8.

Sinai, A; Franaszczuk, PJ; Crone, NE. 2005. Electrocorticographic spectral responses during auditory vs. visual lexical semantic processing. EPILEPSIA 46: 71-72, Suppl. 8.

Kudela, P; Franaszczuk, PJ; Bergey, GK. 2005. Activation of synaptic plasticity by electrical stimulation and its effect on supression of epiletiform activity. EPILEPSIA 46: 112-112, Suppl. 8.

Jouny, CC; Franaszczuk, PJ; Bergey, GK. 2005. The time-frequency signature of partial seizure onsets. EPILEPSIA 46: 317-317, Suppl. 8.

Korzeniewska, A; Kus, R; Franaszczuk, P; Crainiceanu, C; Crone, NE. 2005. Dynamic high-gamma interactions during language-related task performance. EPILEPSIA 46: 317-317, Suppl. 8.

IEEE Neural Engineering'05

Complexity-based Analysis of the Dynamic of Propagation of Epileptic Seizures. Proceedings of the 2nd International IEEE EMBS Conference on Neural Engineering, Arlington, Virginia, March 16 - 19, 2005: p155-157. (abstract - pdf & poster - pdf)

Synaptic and Cellular Influences on the Composite EEG Signal During Seizures. Proceedings of the 2nd International IEEE EMBS Conference on Neural Engineering, Arlington, Virginia, March 16 - 19, 2005: p245-247 (pdf)

EMBS'04

Gabor Atom Density as a Measure of Seizure Complexity. Proceedings of the 26th Annual International Conference of the IEEE EMBS San Francisco, CA, USA September 1-5, 2004: p310-312 vol.1. (pdf)

Software system for data management and distributed processing of multichannel biomedical signals Proceedings of the 26th Annual International Conference of the IEEE EMBS San Francisco, CA, USA September 1-5, 2004: p983-985 vol.2. (pdf)

Synaptic plasticity in neuronal network models can explain patterns of bursting activity seen in temporal lobe epiletic seizures. Proceedings of the 26th Annual International Conference of the IEEE EMBS San Francisco, CA, USA September 1-5, 2004: p715-717 vol.1 (pdf)

AES'04

Seizure evolution can be affected by seizure induced changes in synaptic efficacy. Epilepsia 45 (Suppl. 7):199-200 (2004) (poster - pdf)

Propagation of Partial Seizures is Associated with Increased Signal Complexity Near Seizure Focus. Epilepsia 45 (Suppl. 7):61 (2004) ( poster - pdf)

AES'03

Reduction of intracellular calcium clearance rate can explain changes in seizure dynamics: studies in neuronal network models. Epilepsia 44 (Suppl.9):193 (2003) (poster - pdf)

Changing slow calcium-activated potassium current kinetics influence bursting activity in a model of pyramidal neurons. Epilepsia 44 (Suppl.9):194 (2003) (abstract) (poster - pdf)

Patterns of organized rhythmic activity in neocortical epilepsy. Epilepsia 44 (Suppl.9):230 (2003) (poster - pdf)

CNS'03

The influence of slow calcium-activated potassium channels on epileptiform activity in a neuronal model of pyramidal cells. (abstract) (poster - pdf)

AES'02

Sequential multichannel Gabor atom density for seizure localization. Epilepsia 43 (Suppl.7):47 (2002) (poster - pdf)

A neural network model of neocortical epileptic foci. Epilepsia 43 (Suppl.7):147 (2002) (abstract) (poster)

The influences of GABAA and GABAB inhibition in bursting activity in a model of pyramidal cells. Epilepsia 43 (Suppl.7):149 (2002) (abstract) (Poster - pdf)

CNS'02

The effect of changes in the inhibitory interneuron connectivity on the pattern of bursting behavior in a pyramidal cell model. (text-pdf) (poster - pdf)

AES/ACNS'01

Periodic stimuli can induce oscillating activity in simulated neural networks. Epilepsia 42 (Suppl.7):121 (2001) (abstract) (poster)

Detection of epileptic seizure based on gabor atom density. Epilepsia 42 (Suppl.7):38 (2001). (abstract) (poster - pdf)

Influences of excitatory and inhibitory synaptic connections on the patterns of bursting in a neuronal circuit model. Epilepsia 42 (Suppl.7):122 (2002) (Abstract) (Poster - pdf)

Termination of the spread of bursting activity in a model of connected neural sub-networks. Epilepsia 42 (Suppl.7):209 (2001) (abstract) (slide show)

AES'00

Combined multichannel autoregressive and time-frequency analysis of intracranial recordings of complex partial seizures. Epilepsia 41 (Suppl.7):203 (2000) (abstract) (poster)

Increase in number of synaptic connections increases bursting activity in simulated neural networks. Epilepsia 41 (Suppl.7):6 (2000) (abstract) (poster)

External stimuli terminate bursting in neural network model. Epilepsia 41 (Suppl.7):36-37 (2000) (abstract) (poster)
 

ACNS'00

Analysis of coherence in multiple epileptic seizures. (abstract) (slide show)
 

Chicago 2000

World Congress on Medical Physics and Biomedical Engineering
Realistic modeling of large networks of neurons. Medical Physics 27:1391 (abstract) (slide show)

Fast algorithm for computation of partial coherences from vector autoregressive model coefficients. Medical Physics 27:1389 (abstract) (slide show)

AES'99

Seizure termination in neural network models of neocortical neurons. Epilepsia 40 (Suppl.7):12 (1999) (abstract) (poster)

Decreasing inhibition increases synchronization and burst duration in simulated neural networks. Epilepsia 40 (Suppl.7):12 (1999) (abstract) (poster)

AES'98

A neural network model of traveling seizure activity wave. Epilepsia 39 (Suppl.6):3 (1998) (abstract)

Directed transfer function analysis of participation of mesial temporal structures in complex partial seizures with temporal neocortical onset. Epilepsia 39 (Suppl.6):67 (1998) (abstract) 

Matching pursuit analysis of mesial temporal lobe complex partial seizures suggest increased nonlinear complexity at seizure conclusion. Epilepsia 39 (Suppl.6):206 (1998) (abstract) (poster)

WNM'98

A neural network model of propagation of burst activity. (abstract) (poster)

AES'97

Application of multichannel autoregressive techniques to measure synchronization of cortical EEG during the preictal, ictal, and postictal periods. Epilepsia 38 (Suppl.8):116 (1997) (abstract) (poster) 

AES'96

Application of time-frequency transform analysis to hippocampal activity in mesial temporal seizures. Epilepsia 37 (Suppl.5):144 (1996) (abstract) (poster) 

SFN'96 

Time-frequency analysis of mesial temporal lobe seizures using the matching pursuit algorithm. (abstract) (poster) 

AES'95 

Multichannel autoregressive analysis of propagation of mesial temporal lobe seizures. Epilepsia 36 (Suppl.4):69 (1995) (abstract) (poster) 

Collaborators

Department of Biomedical Physics, Warsaw University, Warsaw, Poland
The Cognitive Neurophysiology Laboratory, JHU
Epilepsy Research Laboratory, Department of Neurology, Johns Hopkins University, Meyer 2-147, 600 N Wolfe St., Baltimore, MD 21287. 


For more information on our research , e-mail us at pfranasz@jhmi.edu.

For clinical information see: EPILEPSY CENTER